Zkdsv Sam E Powder, Quality Product, Free Shipping 100g

Product main function: 1. S-adenosylmethionine (SAMe) is a coenzyme involved in methyl group transfers. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). Transmethylation, transsulfuration and aminopropylation are the metabolic pathways that use SAMe. Although these anabolic reactions occur throughout the body, most SAMe is produced and consumed in the liver. 2. The methyl (CH3) group attached to the methionine sulfur atom in SAMe is chemically reactive. This allows this group to be donated to an acceptor substrate in transmethylation reactions. More than 40 metabolic reactions involve the transfer of a methyl group from SAMe to various substrates such as nucleic acids, proteins and lipids. 3. In bacteria, SAMe is bound by the SAMe riboswitch, which regulates genes involved in methionine or cysteine biosynthesis. Reactions that produce, consume, and regenerate SAMe are called the SAMe cycle. In the first step of this cycle, SAMe-dependent methylases (EC 2.1.1) that use SAMe as a substrate, produce S-adenosyl homocysteine as a product. This is hydrolyzed to homocysteine and adenosine by S-adenosylhomocysteine hydrolase EC 3.3.1.1 and homocysteine is recycled to methionine by transfer of a methyl group from 5-methyltetrahydrofolate, by one of two classes of methionine synthases (EC 2.1.1.13 or EC 2.1.1.14). This methionine can then be converted back to SAMe, completing the cycle.